Peptides, antibodies thereto, and their use in treatment of central nervous system, damage
AssigneeSinapore General Hospital Pte Ltd.
InventorZhi-Cheng Xiao
Life of this patent
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Abstract
The application provides peptides that interact with the inhibitory domains of the myelin proteins Nogo, TNR, and MAG. These may be used in the treatment of CNS damage, and for the development of further treatments. Also provided are methods and materials for immunizing subjects against the inhibitory domains of the myelin proteins, for the treatment of CNS damage.
Claims5
An isolated peptide of up to 8 amino acids in length comprising the amino acid sequence of YLTQPQS (SEQ ID NO:
- 1), wherein the peptide has binding affinity for one or more neuronal growth inhibitor molecules selected from the group consisting of Nogo, Nogo-66 and myelin-associated glycoprotein (MAG).
An isolated peptide consisting of the amino acid sequence of YLTQPQS (SEQ ID NO:
- 1).
A composition for the treatment of spinal cord injury comprising one or more peptides selected from the group consisting of
- (a) a peptide consisting of the amino acid sequence of YLTQPQS (SEQ ID NO:
- 1);
- and
- (b) a peptide of up to 8 amino acids in length comprising the amino acid sequence of YLTQPQS (SEQ ID NO:
- 1), wherein the peptide of (b) has binding affinity for one or more neuronal growth inhibitor molecules selected from the group consisting of Nogo, Nogo-66 and myelin-associated glycoprotein (MAG);
- together with one or more pharmaceutically acceptable ingredients, said composition optionally being formulated for injection.
Dependencies are inferred from the claim text.