Heterocyclic analogs of diphenylethylene compounds

A pharmaceutical composition comprising a therapeutically effective amount of a compound according to formula 1:

• n and m independently represent integers from zero to 4 provided that n+m≦4;
• p and s independently represent integers from zero to 5 provided that p+s≦5;
• a and c represent double bonds which may be present or absent;
• when present, the double bonds may be in the E or Z configuration and, when absent, the resulting stereocenters may have the R- or S-configuration;
• R independently represents a hydrogen atom, linear or branched C1-C20 alkyl, linear or branched C2-C20 alkenyl, —CO2Z′, —CO2R′″, —NH2, —NHR′″, —NR2′″, —OH, —OR′″, a halogen atom, optionally substituted linear or branched C1-C20 alkyl, optionally substituted linear or branched C2-C20 alkenyl, or —CONR2″″;
• R′ independently represents a hydrogen atom, linear or branched C1-C20 alkyl, linear or branched C2-C20 alkenyl, —CO2Z′, —CO2R′″, —NH2, —NHR′″, —NR2′″, —OR′″, a halogen atom, optionally substituted linear or branched C1-C20 alkyl, optionally substituted linear or branched C2-C20 alkenyl, or —CONR2″″;
• R″ independently represents a hydrogen atom, linear or branched C1-C20 alkyl, linear or branched C2-C20 alkenyl, —CO2Z′, —CO2R′″, —NH2, —NHR′″, —NR2′″, —OH, —OR′″, a halogen atom, optionally substituted linear or branched C1-C20 alkyl or optionally substituted linear or branched C2-C20 alkenyl;
• R′″ independently represents linear or branched C1-C20 alkyl or linear or branched C2-C20 alkenyl;
• R″″ independently represents a hydrogen atom, optionally substituted C1-C20 alkyl or optionally substituted C1-C20 alkoxy;
• Z′ represents a hydrogen atom or a pharmaceutically acceptable counter-ion;
• A and A″ each independently represent a hydrogen atom, C1-C20 acylamino;
• C1-C20 acyloxy;
• C1-C20 alkanoyl;
• C1-C20 alkoxycarbonyl;
• C1-C20 alkoxy;
• C1-C20 alkylamino;
• C1-C20 alkylcarboxylamino;
• carboxyl;
• cyano;
• halo;
• or hydroxy;
• B and B″ each independently represent C2-C20 alkenoyl;
• aroyl or aralkanoyl;
• or A and B jointly or A″ and B″ jointly independently represent a methylenedioxy or ethylenedioxy group;
• and
• X and X′ independently represent >NH, >NR′″, —O—, or —S—in a physiologically acceptable carrier.