Substituted N-acyl-2-aminothiazoles

A compound of the formula

• or the pharmaceutically acceptable salts thereof
• wherein R is phenyl or a heterocyclic ring selected from the group consisting of thienyl, pyridinyl, pyrazolyl, imidazolyl, furyl or piperidinyl, which phenyl or heterocyclic ring is optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, hydroxy, nitrile, lower-alkyl, sulfonamido, lower-alkyl-sulfonyl, lower-alkoxy-carbonyl, lower-alkoxy-C(O)—NH—CH2—, benzyl which is optionally substituted with CF3, benzoyl which is optionally substituted with CF3, or phenylsulfonyl
• which is optionally substituted with CF3
• X is —CH2—, —CH2CH2CH2—, —(CH2)3— and O(CH2)—;
• and
• R1 is selected from the group consisting of hydrogen, halogen, lower alkyl, alkoxy or a nitrile group.

A pharmaceutical composition comprising a compound of the formula

• or a pharmaceutically acceptable salt thereof, wherein
• X is —CH2—, —CH2CH2—, —(CH2)3— and O(CH2)—
• R is a 5- or 6-membered saturated or unsaturated carbocyclic or heterocyclic ring which optionally may contain one or more hetero atoms and said rings being optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, lower alkyl, acetamidomethyl, alkoxycarbonyl amidomethyl, a nitrile group, a sulfonamido group, alkylsulfonyl, alkoxy, benzyl, benzoyl, arylsulfonyl and acyl which benzyl, benzoyl, or arylsulfonyl is optionally substituted by halogen, trihalo lower alkyl, lower alkyl, alkoxy, alkylsulfonyl or cyano;
• and
• R1 is selected from the group consisting of hydrogen, halogen, lower alkyl, alkoxy or a nitrile group
• together with a pharmaceutically acceptable excipient.