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US 7,407,970 B2Granted
8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AssigneeNeuroSearch A/S
InventorsDan Peters, Birgitte L. Eriksen, Elsebet Østergaard Nielsen, Jørgen Scheel-Krüger, Gunnar M. Olsen
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Abstract
This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Claims5
An 8-aza-bicyclo[3.2.1]octane derivative of the Formula I:
- or any of its isomers or any mixture of its isomers,
- or a pharmaceutically acceptable salt thereof,
- wherein
- Ra represents hydrogen;
- X represents —O—;
- Rb represents an aryl group selected from monosubstituted phenyl,
- which group is substituted with a substituent selected from the group consisting of
- trifluoromethoxy, cyano, hydroxy, and alkoxy;
- or
- Rb represents an aryl group selected from disubstituted phenyl which group is substituted with substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, and alkoxy;
- or
- Rb represents a heteroaryl group selected from naphthyl, pyridyl, quinolinyl, isoquinolinyl or quinazolinyl, which heteroaryl group is substituted with one or two substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, and alkoxy.
9 more elements
Dependencies are inferred from the claim text.