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AssigneeEpix Delaware, Inc.
InventorsDale S. Dhanoa, Oren Becker, Silvia Noiman, Laurence Wu, Mercedes Lobera, Pradyumna Mohanty, Yael Marantz, Boaz Inbal, Sharon Shacham, Dongli Chen
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The invention relates to 5-HT4 receptor agonists and partial agonists. Thienopyridinone compounds and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT4 receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, Parkinson's disease, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, and nonulcer dyspepsia. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
A compound having the formula
6,7-dihydro-N-(1-ethylpiperidin-4-yl)-4-hydroxy-7-isopropyl-6-oxothieno [2,3-b]pyridine-5-carboxamide, and pharmaceutically acceptable salts thereof.
6,7-Dihydro-4-hydroxy-7-isopropyl-6-oxo-N-(1-propylpiperidin-4-yl)thieno[2,3-b]pyridine-5-carboxamide, and pharmaceutically acceptable salts thereof.
N-(1-Butylpiperidin-4-yl)-6,7-dihydro-4-hydroxy-7-isopropyl-6-oxothieno[2,3-b]pyridine-5-carboxamide, and pharmaceutically acceptable salts thereof.
6,7-Dihydro-4-hydroxy-N-(1-(3-hydroxypropyl)piperidin-4-yl)-7-isopropyl-6-oxothieno[2,3-b]pyridine-5-carboxamide, and pharmaceutically acceptable salts thereof.
N-(1-(Cyclopropylmethyl)piperidin-4-yl)-6,7-dihydro-4-hydroxy-7-isopropyl-6-oxothieno[2,3-b]pyridine-5-carboxamide, and pharmaceutically acceptable salts thereof.
6,7-Dihydro-4-hydroxy-N-(1-isobutylpiperidin-4-yl)-7-isopropyl-6-oxothieno[2,3-b]pyridine-5-carboxamide, and pharmaceutically acceptable salts thereof.
6,7-Dihydro-4-hydroxy-7-isopropyl-6-oxo-N-(1-phenethylpiperidin-4-yl)thieno[2,3-b]pyridine-5-carboxamide, and pharmaceutically acceptable salts thereof.
6,7-Dihydro-4-hydroxy-7-isopropyl-6-oxo-N-(1-pentylpiperidin-4-yl)thieno[2,3-b]pyridine-5-carboxamide, and pharmaceutically acceptable salts thereof.
6,7-Dihydro-7-ethyl-4-hydroxy-6-oxo-N-(1-propylpiperidin-4-yl)thieno[2,3-b]pyridine-5-carboxamide, and pharmaceutically acceptable salts thereof.
6,7-Dihydro-7-ethyl-4-hydroxy-N-(1-(3-hydroxypropyl)piperidin-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carboxamide, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.