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US 7,407,959 B2Granted
Cathepsin cysteine protease inhibitors
AssigneeMerck Frosst Canada, Inc.
InventorsJacques Yves Gauthier, Chun Sing Li, Christophe Mellon
Life of this patent
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Abstract
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
Claims9
A compound of the formula:
- wherein R1 and R2 are taken together with the carbon atom to which they are attached to form a C3-4 cycloalkyl which is optionally substituted with C1-3 alkyl;
- R3 is C1-6 alkyl which is substituted with one to four fluoro or one to four chloro;
- R4 is C1-6 alkyl which is substituted with one to five halo;
- R5 is hydrogen or C1-6 alkyl which is optionally substituted with one to five halo;
- each D is independently aryl or heteroaryl;
- R6 is hydrogen or C1-6 alkyl which is optionally substituted with one to two hydroxyl or two to six halo;
- R7 is C1-6 alkyl which is optionally substituted with two to five halo;
- n is two;
- or a pharmaceutically acceptable salt or stereoisomer thereof.
6 more elements
Dependencies are inferred from the claim text.