2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors

A compound of formula (I):

• wherein:
• R1 is
• wherein X1 is N;
• R2 is H, OH, —O—C1-6 alkyl, —S—C1-6 alkyl, C1-6 alkyl, phenyl, C1-6 haloalkyl, NH2, NH(CH2)n-Ph, NH—C 1-6 alkyl, halo, CN, NO2, CONHR or SO2NHR, wherein R is H or C1-6 alkyl, and n is 0, 1, 2, or 3;
• R3 is H, C1-6 alkyl, C3-7 cycloalkyl, —(CH2)p-NO2, —(CH2)p-NR4R5, —(CH2)p-CHO, —(CH2)p-CONHOH, —(CH2)p-CN, —(CH2)p-CO2H, —(CH2)p-CO2R4, —(CH2)p-CONR4R5, —(CH2)p-tetrazole, —(CH2)p-COR4, —(CH2)q-(COR6)2, —(CH2)p-OR4, (CH2)p-CH═CH—CN, —(CH2)p-CH═CH—CO2H, —(CH2)p-CH═CHCO2R4, —(CH2)pCH═CH—CONR4R5, —(CH2)p-NHCOR4, —(CH2)p-NHCO2R4, —(CH2)p-CONHSO2R4, (CH2)p-NHSO2R4 or —(CH2)p-CH═CH-tetrazole;
• R4 and R5 are independently H or C1-6 alkyl;
• R6 is C1-6 alkyl;
• p is 0, 1, 2, 3, or 4;
• q is 1, 2, 3, or 4;
• X is C1-10 alkylene, C2-10 alkenylene or C2-10 alkynylene;
• one of A1 and A2 is N and the other is NR7;
• and
• R7 is H, OH, C1-6 alkyl, or C3-7 cycloalkyl;
• or a pharmaceutically-acceptable salt or hydrate thereof.