Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity

A compound of formula (Ia)

• or a pharmaceutically acceptable salt or ester thereof;
• wherein A is a thiophenyl moiety that is optionally substituted with one or more of alkyl, aryl, halo, alkoxy, haloalkyl, aryloxy, amino, heteroaryl, or arylalkyl;
• Y is O, S or NR2, wherein R2 is hydrogen or an alkyl group having 1 to 6 carbon atoms;
• and R1 is
• an unbranched alkyl group having from 6 to 25 carbon atoms, a branched alkyl group having from 6 to 25 carbon atoms, an arylalkyl group wherein the alkyl moiety has from 4 to 12 carbon atoms;
• or
• a phenyl group substituted with one or more optionally substituted phenyloxy, phenylthio, SO-phenyl, SO2-phenyl, alkylphenyl, CO-phenyl, CO2-phenyl, CONR16-phenyl, NR16CO-phenyl or NR16-phenyl groups, wherein R16 is hydrogen or an alkyl group having from 1 to 4 carbon atoms, and wherein the phenyloxy, phenylthio, SO-phenyl, SO2-phenyl, alkylphenyl, CO-phenyl, CO2-phenyl, CONR16-phenyl, NR16CO-phenyl or NR16-phenyl groups are optionally substituted with one or more of halo, cyano, nitro, alkyl, alkylhalo, alkoxy, aryl, alkylaryl, aryloxy, amino, hydroxy or heteroaryl;
• or
• a phenyl group substituted with one or more of halo, NR6R7, OR6, SR6, COR6, CO2R6, nitro, cyano, aryl, hetereoaryl, alkyl aryl, alkyl, haloalkyl or alkoxy with the proviso that said compound is not 5-methyl-2-(4-methoxyphenyl)amino-4H-thieno[2,3-d][1,3]oxazin-4-one, 6-pentyl-2-(4-chlorophenyl)amino-4H-thieno[2,3-d][1,3]oxazin-4-one or 6-pentyl-2-(4-methoxyphenyl)amino-4H-thieno[2,3-d][1,3]oxazin-4-one.