Antimicrobial hexapeptides
AssigneeHelix Biomedix, Inc.
InventorsTimothy J. Falla, Lijuan Zhang, Scott M. Harris
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AssigneeHelix Biomedix, Inc.
InventorsTimothy J. Falla, Lijuan Zhang, Scott M. Harris
Estimating the term…
The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such as mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.
A hexapeptide comprising the amino acid sequence given by the formula XBXBOB, wherein X is selected from the group consisting of Arginine (R) and Lysine (K);
A method of inhibiting the growth of a fungal cell comprising:
A method of inhibiting the growth of a fungal cell comprising:
Dependencies are inferred from the claim text.