Leptin peptide antagonists
AssigneeBoston Biomedical Research Institute
InventorsRuben Rene Gonzalez, Paul C. Leavis
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Abstract
Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby inhibiting the up-regulatory effects of leptin on ObR signaling in the leptin-responsive cell. Administration of the peptide effectively prevents embryo implantation in a mammal to which the peptide has been administered. Also disclosed herein is a method for identifying a peptide antagonist of ObR, wherein the peptide comprises a leptin sequence.
Claims7
A method for reducing or inhibiting ObR signaling in a leptin-responsive cell, the method comprising administering to a mammal a therapeutically effective amount of a peptide consisting of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.