Human genes relating to respiratory diseases and obesity
AssigneeOscient Pharmaceuticals Corporation
InventorsTim Keith, Randall Little, Paul Van Eerdewegh, Josée Dupuis, Richard Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
Life of this patent
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Abstract
This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
Claims26
An isolated nucleic acid molecule comprising the nucleotide sequence selected from the group consisting of:
- a) SEQ ID NO. 2, SEQ ID NO. 4, SEQ ID NO. 6, SEQ ID NO. 8, or SEQ ID NO. 10;
- b) the complement of SEQ ID NO. 2, SEQ ID NO. 4, SEQ ID NO. 6, SEQ ID NO. 8, or SEQ ID NO. 10;
- c) a nucleotide sequence comprising at least 500 consecutive nucleotides of SEQ ID NO.2, SEQ ID NO.4, SEQ ID NO. 6, SEQ ID NO. 8, or SEQ ID NO. 10;
- and
- d) the complement of (c).
An isolated DNA or RNA comprising the nucleotide sequence selected form the group consisting of:
- a) 500 consecutive nucleotides of SEQ ID NO. 2, SEQ ID NO. 4, SEQ ID NO. 6, SEQ ID NO. 8, or SEQ ID NO. 10;
- or
- b) the complement of 500 consecutive nucleotides of SEQ ID NO. 2, SEQ ID NO. 4, SEQ ID NO. 6, SEQ ID NO. 8, or SEQ ID NO. 10.
An isolated polynucleotide comprising the nucleotide sequence of SEQ ID NO. 4, wherein position 1389 has a cytosine to thymine substitution.
An isolated nucleic acid fragment comprising at least 500 consecutive nucleotide bases of the nucleotide sequence SEQ ID NO. 1.
Dependencies are inferred from the claim text.