A method of hybridizing two different strains of Cordyceps sinensis at distinct locations in a container and in a solid medium containing purified snake venom, the method comprising the steps of:
- allowing the two strains to grow at the different locations in the solid medium containing purified snake venom until they meet in a boundary zone;
- allowing exchange of nuclear material of the two strains in the boundary zone to form a hybrid strain;
- allowing the hybrid strain to grow, and
- isolating the hybrid strain.