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US 7,407,784 B2Granted
L-amino acid oxidase with cytotoxic activity from Aplysia punctata
AssigneeMax-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
InventorsDaniel Butzke, Sigrid Goedert, Michael Dittrich, Thomas Rudel, Thomas Meyer
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Abstract
The present invention relates to a cytotoxic polypeptide which is an L-amino acid oxidase isolated from the ink of the sea hare Aplysia punctata.
Claims13
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2.
An isolated polypeptide which is a polypeptide which has sequence identity of at least 90% to the polypeptide sequence of SEQ ID NO:
- 2 and which is encoded by a polynucleotide which specifically hybridizes to the full complement of SEQ ID NO:
- 1 under stringent hybridization conditions comprising washing for 1 h with 1 x SSC and 0.1% SDS at 68° C.;
- and which is a L-lysine and /or L-arginine oxidase having the capability to produce H2O2.
Dependencies are inferred from the claim text.