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US 7,407,776 B2Granted
Engineered zinc finger proteins for regulation of gene expression
AssigneeSangamo BioSciences, Inc.
InventorsMichael Moore, Yen Choo, Aaron Klug
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Abstract
Disclosed herein are methods and compositions for modulation of gene expression, with single-gene specificity, in a human-sized genome.
Claims10
An isolated polynucleotide comprising a nucleic acid sequence encoding an engineered zinc finger protein, the engineered zinc finger protein comprising six zinc fingers, each zinc finger comprising a recognition region, wherein the amino acid sequence of the recognition regions, in amino- to carboxy-terminal order, are as follows:
- RSDHLSR (SEQ ID NO:
- 1);
- DNRDRTK (SEQ ID NO:2);
- DRKTLIE (SEQ ID NO:3);
- TSSGLSR (SEQ ID NO:4);
- RSDHLSE (SEQ ID NO:5);
- TSSDRTK (SEQ ID NO:6).
4 more elements
Dependencies are inferred from the claim text.