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US 7,407,769 B2Granted
Method of identifying activity modulators of a polycystin-2L1 taste receptor polypeptide
AssigneeThe Regents of the University of California
InventorsCharles Zuker, Angela L. Huang
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Abstract
Taste receptor polycystin-2L1 is provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, methods of detecting polymorphisms, and methods of correcting taste defects are also provided.
Claims29
A method of identifying a compound that binds to or modulates an activity of a polycystin-2L1 taste receptor polypeptide, the method comprising:
- (a.) contacting a biological or biochemical sample comprising the polycystin-2L1 taste receptor polypeptide with a test compound;
- and,
- (b.) detecting binding of the test compound to the polycystin-2L1 taste receptor polypeptide, or modulation of the activity of the polypeptide by the test compound, thereby identifying the compound which binds to or modulates the activity of the polycystin-2L1 taste receptor polypeptide.
A system for detecting compounds that bind to or modulate an activity of a polycystin-2L1 taste receptor polypeptide, the system comprising:
- (a.) a biological sample comprising the polycystin-2L1 taste receptor polypeptide;
- (b.) a source of a plurality of test compounds;
- and,
- (c.) a detector that detects binding of one or more of the test compounds to the polycystin-2L1 taste receptor polypeptide, or modulation of the activity of the polypeptide by one or more of the test compounds, thereby identifying a putative tastant compound that binds to or modulates the activity of the polycystin-2L1 taste receptor polypeptide.
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Dependencies are inferred from the claim text.