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US 7,407,763 B2Granted
Systems and methods for detecting and regulating metastasis
AssigneeThe Regents of the University of Michigan
InventorsEvan T. Keller, Zheng Fu
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Abstract
The present invention relates to compositions and methods for cancer diagnostics and therapeutics, including but not limited to, RKIP cancer markers and RKIP pathway modulators. In particular, the present invention provides compositions and methods of using RKIP in the diagnosis and treatment of prostate cancers.
Claims5
A method for predicting prostate cancer recurrence, comprising:
- a) providing a resected or biopsied prostate tissue sample from a subject diagnosed with prostate cancer and a resected or biopsied prostate tissue sample from a control-subject diagnosed with non-metastatic prostate cancer,
- b) determining the amount of RKIP protein in said prostate tissue sample from said subject and from said control subject,
- c) comparing said determined amount of RKIP protein in said prostate tissue sample from said subject and said control-subject, and
- d) providing a prognosis to said subject regarding risk of prostate cancer recurrence after treatment for prostate cancer based upon said comparing of RKIP protein amount in said prostate tissue sample from said subject and from said control-subject, wherein said subject has a higher likelihood of prostate cancer recurrence after treatment for prostate cancer if said subject's determined RKIP protein amount is less than said control-subject's determined RKIP protein amount.
1 more element
Dependencies are inferred from the claim text.