Determining a predisposition to cancer
OwnerJan Lubiñski, Janina Suchy +3inventors
InventorsJan Lubiñski, Janina Suchy, Grzegorz Kurzawski, Tadeusz Dêbniak, Cezary Cybulski
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Abstract
The present invention relates to methods and kits for determining a predisposition and surveillance protocols for developing cancer of various sites due to specific mutation in at least one allele of CHEK2 gene and/or at least one allele of NOD2 gene and/or at least one allele of CDKN2A gene.
Claims14
A method for detecting in a human subject a predisposition to breast, stomach, or thyroid cancer comprising obtaining a DNA sample from the human subject, and determining whether an IVS2+1G>A alteration is present in the CHEK2 gene of the human subject, wherein presence of the IVS2+1G>A alteration in the CHEK2 gene is indicative of a predisposition to breast, stomach, or thyroid cancer.
A method for detecting in a human subject a predisposition to colon or kidney cancer comprising obtaining a DNA sample from the human subject, and determining the presence of a I157T alteration in the CHEK2 gene in said DNA sample, wherein presence of the I157T alteration in the CHEK2 gene is indicative of a predisposition to colon or kidney cancer.
Dependencies are inferred from the claim text.