US 7,407,753 B2 · Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis

Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis

AssigneesYissum Research Development Company of the HebrewUniversityofJerusalem, Institut National de la Sante et de la Recherche Medicale, Andreas Zimmer, Meliha Karsak

InventorsAndreas Zimmer, Meliha Karsak, Marie-Christine De Vernejoul, Itai Bab, Esther Shohami, Raphael Mechoulam

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Abstract

The present invention uncovers a highly significant association of SNPs in the CNR2 locus, encoding the cannabinoid receptor 2 protein, with osteoporosis. Methods and kits for determining predisposition to osteoporosis, improving diagnosis in individuals suspected of having osteoporosis are provided. Also provided a method of identifying a putative osteoporosis-causing genetic mutation in a subject.

Claims1

Dependent claims

A method of determining if a human individual is predisposed to osteoporosis, the method comprising:

obtaining a nucleic acid sample from said human individual and analyzing said nucleic acid sample to determine the identity of a polymorphic variant at position 26 of SEQ ID NO:
14;
wherein the presence of a guanine at position 26 of SEQ ID No:
14 is indicative of a predisposition to osteoporosis.

1 more element

Dependencies are inferred from the claim text.