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US 7,407,751 B2Granted
Methods for the detection and prognosis of breast tumors
AssigneeWilex AG
InventorsThomas Luther, Viktor Magdolen, Manfred Schmitt, Matthias Kotzsch
Life of this patent
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Abstract
This invention relates to the production of specific antibodies for the detection of human tumor associated urokinase-type plasminogen activator receptor (uPAR) deletion variants in biological samples as well as to their diagnostic and therapeutic application.
Claims11
A method for the detection of a breast tumors associated with the generation of at least one uPAR deletion variant comprising the steps of:
- (a) obtaining a cDNA containing sample from a breast tumor to be investigated, and
- (b) analyzing the cDNA of said sample to determine whether alternative splicing of uPAR has occurred and at least one uPAR deletion variant has been generated, wherein the at least one uPAR deletion variant is del4+5, wherein the tumor sample is obtained from a human patient, and
- wherein the presence of the at least one uPAR deletion variant in said tumor indicates the presence of a tumor associated with the generation of at least one uPAR deletion variant.
A method of providing a prognosis for a breast tumor-bearing patient comprising the steps of:
- (a) obtaining a cDNA containing sample from a breast tumor of said patient,
- (b) analyzing the cDNA of said sample to determine whether alternative splicing of uPAR has occurred and at least one uPAR deletion variant has been generated, wherein the at least one uPAR deletion variant is del4+5, and
- (c) correlating the presence of the at least one uPAR deletion variant in the tumor of the patient with a prognosis of the patient.
Dependencies are inferred from the claim text.