US 7,407,661 B2 · Methods and reagents that generate a CD8 T cell immune response

Abstract

New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.

Claims25

Dependent claims

A method for generating a CD8+ T cell immune response in a human against hepatitis B comprising administering to said human at least one dose of each of the following:

(i) a priming composition comprising one or more CD8+ T cell epitopes of hepatitis B, which are present in, or encoded by, a non-viral vector, or a viral vector that is non-replicating or replication-impaired in the human;
and
(ii) a boosting composition comprising a recombinant poxvirus vector encoding at least one of said one or more CD8+ T cell epitopes of hepatitis B, wherein the recombinant poxvirus vector is non-replicating or replication-impaired in the human;
wherein the viral vector in (i) is derived from a different virus than the viral vector in (ii), and wherein the CD8+ T cell immune response against hepatitis B causes a reduction in hepatitis B viral load in the human.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

10/833,744Filed 28 Apr 2004 · continuation

Priority

GB 9711957.29 Jun 1997

Published

US 2004/0131594 A17 Oct 2004

Granted

5 Aug 2008

Term ends

Not estimatedThe source records don’t support an estimate.

Classification39 codes

C12N 15/86
For animal cells: viral vectors
A61K 38/1709
From vertebrates: from mammals
A61K 39/0011
Vertebrate antigens: cancer antigens
A61K 39/015
Protozoa antigens: hemosporidia antigens, e.g. Plasmodium antigens

Family

PCT/GB98/01681Parent of this continuation · filed 9 Jun 1998

Application09/454,204Parent of this continuation · filed 9 Dec 1999

Application09/454,204Parent of this division · filed 9 Dec 1999

Application10/653,624Parent of this continuation · filed 2 Sep 2003

Application10/686,943Parent of this continuation · filed 16 Oct 2003

US 2004/0197349 A1Pre-grant publication · published 7 Oct 2004

US 6,663,871 B1Parent of this continuation

US 6,663,871 B1Parent of this division

Application10/653,624Parent of this division

US 2004/0131594 A1Published application

US 2004/0213799 A1Published application

US 7,407,661 B2This patent

From the US filing history. Foreign family members aren’t listed.

Methods and reagents that generate a CD8 T cell immune response

Life of this patent

Methods and reagents that generate a CD8 T cell immune response

Life of this patent

Abstract

Claims25