Peptides for the treatment of cancer associated with the human papilloma virus (HPV) and other epithelial tumors

A pharmaceutical composition comprising

• a). a peptide selected from the group consisting of
• i). CSVRQGPVQKC (SEQ ID NO:
• 1);
• ii). CSSCQNSPALC (SEQ ID NO:
• 2);
• iii). CQIPQRTATRC (SEQ ID NO:
• 3);
• iv). CAKQRTDPGYC (SEQ ID NO:
• 4);
• v). CWMSPRHLGTC (SEQ ID NO:
• 5);
• vi). CRNCTVIQFSC (SEQ ID NO:
• 6);
• vii). CHYIAGTVQGC (SEQ ID NO:
• 7);
• viii). CPLVSLRDHSC (SEQ ID NO:
• 8);
• ix). CKQSYLHHLLC (SEQ ID NO:
• 9);
• x). CFQPLTPLCRC (SEQ ID NO:
• 10);
• xi). CQSYHELLLQC (SEQ ID NO:
• 11);
• and
• b). a pharmaceutically-acceptable carrier.

A method for inhibiting tumor cell proliferation, comprising administering to a mammal an effective amount of a peptide comprising an amino acid sequence as set forth in:

• a). CSVRQGPVQKC (SEQ ID NO:
• 1);
• b). CSSCQNSPALC (SEQ ID NO:
• 2);
• c). CQIPQRTATRC (SEQ ID NO:
• 3);
• d). CAKQRTDPGYC (SEQ ID NO:
• 4);
• e). CWMSPRHLGTC (SEQ ID NO:
• 5);
• f). CRNCTVIQFSC (SEQ ID NO:
• 6);
• g). CHYIAGTVQGC (SEQ ID NO:
• 7);
• h). CPLVSLRDHSC (SEQ ID NO:
• 8);
• i). CKQSYLHHLLC (SEQ ID NO:
• 9);
• j). CFQPLTPLCRC (SEQ ID NO:
• 10);
• or
• k). CQSYHELLLQC (SEQ ID NO:
• 11),
• wherein the peptide binds and inhibits a Casein Kinase II (CKII) phosphorylation site.

A mammalian expression vector comprising a nucleotide sequence that encodes a peptide comprising an amino acid sequence as set forth in:

• a). CSVRQGPVQKC (SEQ ID NO:
• 1);
• b). CSSCQNSPALC (SEQ ID NO:
• 2);
• c). CQIPQRTATRC (SEQ ID NO:
• 3);
• d). CAKQRTDPGYC (SEQ ID NO:
• 4);
• e). CWMSPRHLGTC (SEQ ID NO:
• 5);
• f). CRNCTVIQFSC (SEQ ID NO:
• 6);
• g). CHYIAGTVQGC (SEQ ID NO:
• 7);
• h). CPLVSLRDHSC (SEQ ID NO:
• 8);
• i). CKQSYLHHLLC (SEQ ID NO:
• 9);
• j). CFQPLTPLCRC (SEQ ID NO:
• 10);
• or
• k). CQSYHELLLQC (SEQ ID NO:
• 11).