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US 7,317,091 B2Granted
Optimized Fc variants
AssigneeXencor, Inc.
InventorsGregory Alan Lazar, Arthur J. Chirino, Wei Dang, John R. Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
Life of this patent
Estimating the term…
Abstract
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
Claims1
An antibody or an immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid modification at position 332 in the Fc region of said parent Fc polypeptide, wherein said antibody or immunoadhesin exhibits altered binding to an FcγR as compared to said parent Fc polypeptide, wherein numbering is according to the EU index.
Dependencies are inferred from the claim text.