US 7,303,752 B2Granted

Hookworm vaccine

AssigneeThe George Washington University

InventorsPeter Hotez, James Ashcom, Mahnaz Bdamchian, Bin Zhan, Yan Wang, John Hawdon, Alexander Loukas, Angela Williamson, Brian Jones, Jeffrey Bethony, Gaddam Goud, Maria Elena Bottazzi, Susana Mendez

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Abstract

Preparations which elicit an immune response to hookworm antigens and which may be utilized as hookworm vaccines are provided. In addition, a method of increasing the effectiveness of vaccinations against infectious diseases in patients infected with hookworm is provided. The method involves chemically treating the hookworm infestation prior to administering the vaccine.

Claims4

Dependent claims

A method of reducing the worm burden of human hookworm Necator americanus in a mammal or eliciting an immune response in said mammal comprising the step of:

administering to said mammal an effective amount of a composition comprising Na-ASP-2 having the amino acid sequence of SEQ ID NO:69;
an adult stage hookworm antigen selected from the group consisting of Na-APR-1 having the amino acid sequence of SEQ ID NO:8 and Na-CP-2 having the amino acid sequence of SEQ ID NO:84;
and at least one adjuvant, wherein the immune response is directed against the Necator americanus antigens of the administered composition.

Dependencies are inferred from the claim text.

Facts

Application: 10/825,692Filed 16 Apr 2004 · continuation in part
Priority: 17 Oct 2001
Published: US 2005/0042232 A124 Feb 2005
Granted: 4 Dec 2007
Term ends: Not estimatedThe source records don’t support an estimate.

Classification5 codes

A61K 39/0003
Medicinal preparations containing antigens or antibodies: invertebrate antigens
A61K 2039/55577
Organic adjuvants: saponins; quil a; qs21; iscoms
Y02A 50/30
In human health protection, e.g. against extreme weather: against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne…
A61K
Medicines and medical preparations

Family

Application60/329,533Us provisional application · filed 17 Oct 2001
Application60/332,007Us provisional application · filed 23 Nov 2001
Application60/375,404Us provisional application · filed 26 Apr 2002
PCT/US02/33106Parent of this continuation-in-part · filed 17 Oct 2002
Application60/505,848Us provisional application · filed 26 Sep 2003
US 2005/0042232 A1Pre-grant publication · published 24 Feb 2005
US 7,303,752 B2This patent

From the US filing history. Foreign family members aren’t listed.

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