Method of modulating laser-accelerated protons for radiation therapy
AssigneeFox Chase Cancer Center
InventorsChang-Ming Ma, Eugene S. Fourkal
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Abstract
Methods of optimizing a laser-accelerated proton radiation dose to a targeted region are disclosed. Disclosed methods include providing a plurality of modulated polyenergetic proton beamlets and irradiating the targeted region with the plurality of modulated beamlets.
Claims38
A method of generating a positive ion beam sequence for providing a prescriptive dose of high energy polyenergetic positive ions to a target volume, comprising the steps of:
- a) providing a plurality of beam angles, plan prescription, and dose constraints;
- b) providing a plan optimization process based on a beam scanning sequence;
- c) applying said beam scanning sequence to said beam angles, plan prescription and dose constraints to generate plan optimization results;
- d) comparing the plan optimization results to the plan prescription;
- and
- e) modulating the beam scanning sequence and iteratively repeating steps b), c) and d) until the plan optimization results are acceptable.
A method of providing a prescriptive dose of high energy polyenergetic positive ions to a target volume, comprising the steps of:
- a) providing a plurality of beam angles, plan prescription, and dose constraints;
- b) providing a plan optimization process based on a beam scanning sequence;
- c) applying said beam scanning sequence to said beam angles, plan prescription and dose constraints to generate plan optimization results;
- d) comparing the plan optimization results to the plan prescription;
- e) modulating the beam scanning sequence and iteratively repeating steps b), c) and d) until the plan optimization results are acceptable;
- and
- f) irradiating the target volume with a plurality of beamlets according to the plan optimization results.
A method of providing a proton radiation dose to a targeted region, comprising:
- providing a plurality of modulated polyenergetic proton beamlets;
- and
- irradiating said targeted region with said plurality of modulated polyenergetic proton beamlets.
A method of providing a positive ion radiation dose to a targeted region, comprising:
- providing a plurality of modulated polyenergetic positive ion beamlets;
- and
- irradiating said targeted region with said plurality of modulated polyenergetic positive ion beamlets, wherein each of said polyenergetic beamlets is modulated, individually, according to at least one of:
- beamlet energy distribution, beamlet intensity, beamlet direction, beamlet area, or beamlet shape.
A method of providing a proton radiation dose to a targeted region, comprising:
- providing a plurality of modulated polyenergetic proton beamlets, wherein each of said polyenergetic beamlets is modulated, individually, according to at least one of:
- beamlet energy distribution, beamlet intensity, beamlet direction, beamlet area, or beamlet shape;
- and
- irradiating said targeted region with said plurality of modulated polyenergetic proton beamlets, wherein said plurality of modulated polyenergetic proton beamlets maximizes said proton radiation dose to the targeted region and minimizes said proton radiation dose to areas external to the targeted region.
A method of providing a prescriptive dose to a targeted region in a patient, comprising:
- a) providing a plurality of polyenergetic proton beamlets;
- and
- b) modulating said polyenergetic proton beamlets, wherein said modulating gives rise to an acceptable dose distribution to the targeted region according to the prescriptive dose in both longitudinal and lateral directions relative to said beamlets.
A method of providing a positive ion radiation dose, comprising:
- a) providing a plurality of polyenergetic positive ion beamlets;
- and
- b) modulating said polyenergetic positive ion beamlets, wherein said modulating gives rise to a desired dose distribution based on a prescribed dose to a target in both longitudinal and lateral directions relative to said beamlets.
A method of providing intensity modulated proton therapy to a targeted region in a patient, comprising:
- providing a plurality of high energy positive ion beamlets;
- modulating at least one of the high energy positive ion beamlets in depth relative to the patient to provide a depth-modulated beamlet;
- modulating at least one of the depth-modulated beamlets in a lateral direction relative to the patient to provide a lateral-modulated beamlet;
- and
- irradiating said targeted region with at least one of the lateral-modulated beamlets to the patient.
Dependencies are inferred from the claim text.