Virulent systemic feline calicivirus
AssigneeThe Regents of the University of California
InventorsJanet E. Foley, Kate Hurley, Niels C. Pedersen, Amy Poland
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Abstract
The present invention relates to a vaccine for immunization against a viral infection caused by a virulent systemic feline calicivirus (VS-FCV), a novel, atypical and unusually virulent form of a calicivirus that results in a highly contagious and fatal hemorrhagic fever syndrome. The present invention further encompasses methods of immunizing cats against particular strains of VS-FCV.
Claims10
An isolated virulent systemic calicivirus (VS-FCV), wherein said virus causes a highly contagious hemorrhagic fever syndrome in cats with symptoms selected from the group consisting of high fever, edema, ulceration, hair loss, nasal and ocular discharge, anorexia, depression, and death, wherein treatment of said cats with an immunologically effective dose of FCV-F9 achieves substantially no protection against infection with VS-FCV;
- and wherein said VS-FCV comprises a capsid protein including lysine at amino acid position 448;
- glutamic acid at amino acid position 452;
- and lysine or aspartic acid at amino acid position 581 when optimally aligned with the capsid protein of SEQ ID NO:1.
Dependencies are inferred from the claim text.