US 7,238,693 B2 · Aryl carbamate derivatives, preparation and use thereof

Aryl carbamate derivatives, preparation and use thereof

AssigneesCerep SA, Centre National De La Recherche Scientifique, Institut National de la Santa et de la Recherche Medicale (Inserm)

InventorsEric Nicolai, Sophie Curtet, James Sicsic, Frank Lezoualc'h, Rodolphe Fischmeister, Michel Langlois, Magali Maillet, Michèle Launay

Life of this patent

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Abstract

The present invention relates to novel compounds, the preparation and use, particularly therapeutic, thereof. More specifically, it relates to compounds derived from aryl carbamates, the preparation and use thereof, particularly in the field of human and animal health. The compounds according to the invention are preferably 5-HT4 serotoninergic receptor ligands and can therefore be used in the therapeutic or prophylactic treatment of any disorder involving a 5-HT4 receptor. The invention also relates to pharmaceutical compositions comprising such compounds, the preparation and use thereof and treatment methods using said compounds. Compounds according to the invention include compounds of the following formula (I):

Claims8

Dependent claims

A compound represented by the general formula (I):

wherein
R1 represents a lower alkyl group,
R2 represents the hydrogen atom,
R3 represents a heterocycle, chosen from among, pyrimidinyl, pyridazinyl or pyrazinyl, such group optionally being substituted by one or more groups chosen from among halogeno, cyano, nitro, alkyl or halogenoalkyl,
Y represents an alkylene bond or chain, linear or branched, having 2 or 3 to 5carbon atoms,
J represents a C—R7 group,
G represents a C—R5 group,
R4, R5, R6 and R7 represent the hydrogen atom,
n is equal to 1, and the salts thereof.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/467,932Filed 22 Feb 2002

Priority

FR 01 0243123 Feb 2001

Published

US 2004/0058933 A125 Mar 2004

Granted

3 Jul 2007

Term ends

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Classification18 codes

C07D 213/74
Nitrogen atoms: amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system
A61P 9/00
Drugs for disorders of the cardiovascular system
A61P 13/00
Drugs for disorders of the urinary system