Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them

A compound of the formula

• wherein
• Φ is phenylene with 1 to 2 substituents selected from the group consisting of hydrogen, halogen, —OH, and alkyl or alkoxy of 1 to 6 carbon atoms;
• A is
• W is a bond;
• R1, R2, R3, R4, R5 are individually selected from the group consisting of hydrogen, halogen, —OH, alkyl or alkoxy of 1 to 6 carbon atoms, cyano, nitro and —NR6R7;
• R6 and R7 are individually selected from the group consisting of hydrogen, —OH, alkyl or alkoxy of 1 to 6 carbon atoms, and —COR8,
• R8 is selected from the group consisting of hydrogen, —OH, alkyl or alkoxy of 1 to 6 carbon atoms, and —NR9R10,
• R9 and R10 are individually selected from the group consisting of hydrogen, —OH or alkyl of 1 to 6 carbon atoms,
• B is selected from the group consisting of —CH2—NO2;
• alkyl of 1 to 6 carbon atoms;
• —NR13R14;
• and unsubstituted or substituted carbocyclic aryl or heterocyclic aryl carbocyclic or heterocyclic aryl of 5 to 6 ring members containing 1 to 4 heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen, the aryl substituents being selected from the group consisting of alkyl alkenyl and alkoxy of up to 6 carbon atoms,
• R13 and R14 are individually selected from the group consisting hydrogen, alkyl of 1 to 6 carbon atoms, cyano, nitro radical, or together with the nitrogen form a non aromatic heterocycle of 5 to 6 ring members, selected from the group consisting of —CH2—, —NH—, —O—or —S—;
• X is selected from the group consisting of a bond, —(CH2)k—NR16—, —O—, —S—, —CO—, —NR16—CO—, —CO—NR16—, —O—CO—, —CO—O—, —NR16—CO—O—, —NR16—CO—NR17—,
• k representing 0 or 1;
• Y is selected from the group consisting of a bond, —(CH2)m—, —(CH2)m—O—(CH2)n—, —(CH2)m—S—(CH2)n—, —(CH2)m—NR18—(CH2)n—, —(CH2)m—NR18—CO—(CH2)n—, —(CH2)m—CO—NR18—(CH2)n—, —(CH2)m-Q-(CH2)n—,
• Q is selected from the group consisting of piperazine, homopiperazine, 2-methylpiperazine, 2,5-dimethylpiperazine, 4-oxypiperidine or 4-aminopiperidine radicals,
• m and n are individually integers from 0 to 6;
• R16, R17 and R18 are individually hydrogen or akyl of 1 to 6 carbon atoms;
• and a pharmaceutically acceptable salt thereof.