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US 7,122,143 B2Granted
Methods for manufacturing dosage forms
AssigneeMcNeil-PPC, Inc.
InventorsHarry S. Sowden, Bernard F. Plantz, Shun Por Li
Life of this patent
Estimating the term…
Abstract
Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.
Claims22
A method of making a dosage form containing a first medicant, which comprises
- a) injecting through a nozzle that moves for injection and then retracts away from a mold cavity to close the mold cavity a flowable material containing said first medicant into said mold cavity, wherein the nozzle comprises valve body and tip, and after injection, the nozzle is retracted and the tip closes the mold cavity;
- and
- b) hardening by cooling within the mold cavity said flowable material into a solid molded dosage form having a shape substantially the same as the mold cavity, wherein substantially all of the flowable material injected into the mold cavity becomes part of the solid molded dosage form.
A method of making a molded dosage form which comprises
- a) heating a flowable material containing a pharmaceutical active ingredient;
- b) injecting said flowable material through a nozzle that moves for injection and then retracts away from a mold cavity to close the mold cavity wherein the nozzle comprises a valve body tip, and after injection, the nozzle is retracted and the tip closes the mold cavity having an orifice into said mold cavity;
- and
- c) hardening said flowable material into a solid molded dosage form having a shape substantially the same as the mold cavity;
- wherein said hardening step (c) comprises cooling said flowable material and wherein said mold cavity is heated prior to said injecting step (b) and cooled during said hardening step (c), wherein substantially all of the flowable material injected into the mold cavity becomes part of the solid molded dosage form.
2 more elements
Dependencies are inferred from the claim text.