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US 7,078,541 B2Granted
Benzofuran derivatives
AssigneeGalileo Pharmaceuticals, Inc.
InventorsSekhar Boddupalli, Gail Walkinshaw, Bing Wang
Life of this patent
Estimating the term…
Abstract
Certain benzofuran derivatives are useful in the treatment of certain ischemic or inflammatory conditions, as well as neuroinflammation, neurodegeneration or degenerative diseases in which mitochondrial dysfunction leads to tissue degeneration. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.
Claims20
A compound represented by Formula II:
- wherein:
- R6 :
- hydrogen, optionally substituted (C1–C8)-alkyl, optionally substituted (C2–C10) -alkenyl, optionally substituted aryl, (optionally substituted (C1–C8) -alkoxy)carbonyl, or halogen;
- R7 and R8 are independently selected from optionally substituted (C1–C6)-alkyl, optionally substituted (C2–C10)-alkenyl, or optionally substituted (C3–C8)-cycloalkyl;
- R9 is:
- optionally substituted aryl, (optionally substituted(C1–C8)- alkyl)carbonyl, (optionally substituted aryl)carbonyl, (optionally substituted heterocyclyl)carbonyl, (optionally substituted heterocyclylalkyl)carbonyI, (optionally substituted (C1–C8) -alkoxy)carbonyl, (optionally substituted (C2–C10)-alkenyloxy)carbonyl, (optionally substituted amino)carbonyl, carboxy, formyl, or hydroxy(optionally substituted)(C1–C8)-alkyl;
- R10 is:
- (C1–C6)-alkyl, (C2–C10)-alkenyl, or amino;
- and
- R′is:
- hydrogen, (C1–C6)-alkyl, (C1-C6)-alkylcarbonyl, phosphoryl, or polyalkoxy;
- or
- R′and R8 with the atoms to which they are attached form an optionally substituted ring;
- with the proviso that the compound is not (5-hydroxy-3,6,7-trimethyl-benzofuran-2-yl)-phenyl -methanone or 3-amino-5-hydroxy4,6,7-trimethyl-benzofuran-2-carboxylic acid ethyl ester;
- and single stereoisomers, mixtures of stereoisomers, and the pharmaceutically acceptable salts thereof.
12 more elements
Dependencies are inferred from the claim text.