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AssigneeTransform Pharmaceuticals, Inc.
InventorsJules Remenar, Michael MacPhee, Matthew Lynn Peterson, Sherry Lynn Morissette, Orn Almarsson
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The invention provides novel soluble conazole crystalline forms (e.g. itraconazole, posaconazole and saperconazole) that include salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these conazole crystalline forms. Methods of using such compositions for the treatment or prevention of systemic and local fungal, yeast, and dermatophyte infections are also provided.
A composition comprising a co-crystal of cis-itraconazole, wherein said co-crystal is a tartaric acid co-crystal of a cis-itraconazole HCl salt, and further wherein said co-crystal has an endothermic transition at about 161 degrees C. as determined by DSC.
A composition comprising a co-crystal of cis-itraconazole, wherein said co-crystal is a tartaric acid co-crystal of a cis-itraconazole HCl salt, and further wherein said co-crystal is characterized by an X-ray diffraction pattern, wherein:
A composition consisting of a co-crystal of cis-itraconazole, wherein said co-crystal is a tartaric acid co-crystal of a cis-itraconazole HCl salt, and further wherein said co-crystal has an endothermic transition at about 161 degrees C. as determined by DSC.
A composition consisting of a co-crystal of cis-itraconazole, wherein said co-crystal is a tartaric acid co-crystal of a cis-itraconazole HCl salt, and further wherein said co-crystal is characterized by an X-ray diffraction pattern, wherein:
A method of making a co-crystal of cis-itraconazole, comprising:
A method of making a co-crystal of cis-itraconazole, comprising:
Dependencies are inferred from the claim text.