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US 7,078,524 B2Granted
Process for the synthesis of ganciclovir
AssigneeRanbaxy Laboratories Limited
InventorsJayachandra Suresh Babu, Purna Chandra Ray, Yatendra Kumar, Chandra Has Khanduri
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Abstract
The present invention relates to an industrial useful process for the synthesis of antiviral compound, ganciclovir which comprises dissolving a mixture containing N-7 and N-9 isomers of structural formulae, II and III, respectively: in a solvent or a mixture of solvents; separating the N-7 and N-9 isomers; and hydrolizing the N-9 isomer to obtain ganciclovir.
Claims12
A process for the separation of N-7 and N-9 isomers of structural formulae II and III, respectively:
- wherein Ac represents acetyl, the process comprising disolving a mixture containing the N-7 and N-9 isomers in one or more alcoholic solvents to get a solution;
- separating the N-7 isomer from the solution thereof by filtration;
- removing the solvent from filtrate to obtain a residue;
- adding another solvent or a mixture of solvents, wherein the solvent comprises one or more of alcoholic solvents and water immiscible solvents;
- and isolating the N-9 isomer.
2 more elements
Dependencies are inferred from the claim text.