US 7,078,492 B2 · Human antipneumococcal antibodies from non-human animals

Abstract

The invention described herein provides human antibodies produced in non-human animals that specifically bind to Streptococcus pneumoniae capsular polysaccharide (PPS-3). The invention further provides methods for making the antibodies in a non-human animal and for expressing the antibodies in cells including hybridomas and recombinant host cell systems. Kits and pharmaceutical compositions comprising the antibodies are also provided in addition to methods of treating, inhibitng or preventing S. pneumoniae infection or conditions or disorders caused by such infection by administering to a patient the pharmaceutical compositions described herein.

Claims11

Dependent claims

A monoclonal antibody or an antigen-binding fragment thereof that specifically binds the capsular polysaccharide of Streptococcus pneumoniae serotype 3 (S. pneumoniae PPS-3), wherein said antibody or fragment comprises a heavy chain amino acid sequence comprising an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence encoded by the DNA sequence set forth in SEQ ID NO:
1;
(b) the amino acid sequence of residues 31 to 104, inclusive, of the amino acid sequence encoded by the DNA sequence set forth in SEQ ID NO:
1;
and
(c) the CDR1, CDR2 and CDR3 amino acid sequences encoded by the DNA sequence set forth in SEQ ID NO:
1.

4 more elements

Dependencies are inferred from the claim text.

Human antipneumococcal antibodies from non-human animals

Life of this patent

Human antipneumococcal antibodies from non-human animals

Life of this patent

Abstract

Claims11