US 7,078,487 B2Granted

PTH1R receptors

AssigneeThe General Hospital Corporation

InventorsHarald Jüppner, David A Rubin

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Abstract

The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.

Claims7

Dependent claims

An isolated PTH1R polypeptide selected from the group consisting of:

(a) the amino acid sequence of the PTH1R polypeptide having the complete amino acid sequence from positions 1 to 536 in SEQ ID NO:2;
(b) the amino acid sequence of the PTH1R polypeptide having the amino acid sequence from positions 2 to 536 in SEQ ID NO:2;
(c) the amino acid sequence of the mature PTH1R polypeptide having the amino acid sequence from positions 25 to 536 in SEQ ID NO:2;
(d) the amino acid sequence of the PTH1R polypeptide having the complete amino acid sequence encoded by the cDNA clone deposited with the ATCC as patent deposit PTA-916;
(e) the amino acid sequence of the mature PTH1R polypeptide having the amino acid sequence encoded by the eDNA clone deposited with the ATCC as patent deposit PTA-916;
(f) the amino acid sequence of the PTH1R receptor extracellular domain, said extracellular domain having the amino acid sequence from position 25 to position 147 in SEQ ID NO:2;
(g) the amino acid sequence of the PTH1R receptor transmembrane domain, said transmembrane domain consisting of the amino acid sequence from position 148 to position 416 in SEQ ID NO:2.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/372,095Filed 25 Feb 2003 · division
Priority: 30 Nov 1998
Published: US 2003/0162256 A128 Aug 2003
Granted: 18 Jul 2006
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07K 14/461
From vertebrates: from fish
A61P 5/18
Drugs for disorders of the endocrine system: of the parathyroid hormones
C07K 14/723
For hormones: g protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
A61K 38/00
Medicinal preparations containing peptides

Family

Application60/110,467Us provisional application · filed 30 Nov 1998
Application09/449,632Parent of this division · filed 30 Nov 1999
US 2003/0162256 A1Pre-grant publication · published 28 Aug 2003
US 6,451,220 B1Parent of this division
US 6,541,220 B1Related patent
US 7,078,487 B2This patent

From the US filing history. Foreign family members aren’t listed.

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