US 7,078,483 B2 · Retroviral vectors including modified envelope escort proteins

Abstract

A retroviral vector comprising a first retroviral envelope protein and at least one modified retroviral envelope protein, wherein the first retroviral envelope protein includes a surface protein comprising (i) a receptor binding region; (ii) a hypervariable polyproline region; and (iii) a body portion, and the modified retroviral envelope protein, prior to modification, includes a surface protein which includes (i) a receptor binding region; (ii) a hypervariable polyproline region; and (iii) a body portion, characterized in that the modified retroviral envelope protein has been modified such that at least 90% of the amino acid residues of the receptor binding region of the surface protein of the modified retroviral envelope protein have been removed and replaced with a non-retroviral protein or peptide.

Claims2

Dependent claims

A modified retroviral envelope protein, wherein prior to modification, the retroviral envelope protein included a surface protein comprising:

(i) a receptor binding region having the sequence of SEQ ID NO:
1;
(ii) a hypervariable polyproline region having the sequence of SEQ ID NO:
2;
and (iii) a C-terminus of said surface protein, wherein said modified retroviral envelope protein has been modified such that at least 90% of the amino acid residues of the receptor binding region and residues 1 through 35 of SEQ ID NO:
2 have been removed and replaced with a non-retroviral protein or peptide.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/223,599Filed 19 Aug 2002 · continuation

Priority

29 Apr 1998

Published

US 2003/0129163 A110 Jul 2003

Granted

18 Jul 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C12N 15/86
For animal cells: viral vectors
C12N 2740/13043
Use of virus, viral particle or viral elements as a vector: viral genome or elements thereof as genetic vector
C12N 2740/13045
Use of virus, viral particle or viral elements as a vector: special targeting system for viral vectors
C12N 2810/40
Vectors comprising a targeting moiety: vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source

Family

Application09/069,398Parent of this continuation-in-part · filed 29 Apr 1998

PCT/IB99/00764Parent of this continuation · filed 28 Apr 1999

Application09/698,545Parent of this continuation · filed 27 Oct 2000

US 2003/0129163 A1Pre-grant publication · published 10 Jul 2003

PCT/IB99/00764Parent of this continuation-in-part

US 7,078,483 B2This patent

From the US filing history. Foreign family members aren’t listed.

Retroviral vectors including modified envelope escort proteins

Life of this patent

Retroviral vectors including modified envelope escort proteins

Life of this patent

Abstract

Claims2