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US 7,078,435 B2Granted
Autoinducer compounds
AssigneeMontana State University
InventorTom Livinghouse
Life of this patent
Estimating the term…
Abstract
Autoinducer compounds which enhance gene expression in a wide variety of microorganisms, therapeutic compositions and therapeutic methods wherein gene expression within microorganisms is regulated are disclosed.
Claims24
A compound of the following formula:
- wherein R1–R21 are selected from the group consisting of H, C1–C4 alkyl group, OH, NH2, SH and a halogen, wherein the halogen is selected from the group consisting of fluorine, chlorine, bromine, and iodine;
- R22 and R23 are selected from H, S, O, and N—Y,
- Y is selected from H, C1–C4 alkyl group, OH, NH2, SH or a halogen, wherein the halogen is selected from the group consisting of fluorine, chlorine, bromine, and iodine,
- R24–R28 is H or a halogen,
- X1 and X2 are selected from O, S, NH, H2, H plus OH or NH2, or any combination of H plus one halogen or two halogens when one or more R groups is substituted, and at least one of R1–R21 is halogen, or the alkylene chain of the molecule contains a sulfur in the chain;
- and
- wherein the alkylene chain of the molecule contains a nitrogen in the chain, or the alkylene chain of the molecule contains one or more double bonds or triple bonds between the carbon atoms within the chain, or the homoserine lactone portion of the molecule contains a sulfur in the ring.
4 more elements
A compound of the following formula:
- wherein R1–R7 are selected from the group consisting of H, C1–C4 alkyl group, OH, NH2, SH or a halogen, wherein the halogen is selected from the group consisting of fluorine, chlorine, bromine, and iodine;
- R22 and R23 are selected from H, S, O, and N—Y,
- Y is selected from H, C1–C4 alkyl group, OH, NH2, SH or a halogen, wherein the halogen is selected from the group consisting of fluorine, chlorine, bromine, and iodine,
- R24–R28 is H or a halogen,
- X is selected from O, S, NH, H2, H plus OH or NH2, or any combination of H plus one halogen or two halogens when one or more R groups is substituted, and at least one of R1–R7 is halogen, or the alkylene chain of the molecule contains a sulfur in the chain;
- and
- wherein the alkylene chain of the molecule contains a nitrogen in the chain, or the alkylene chain of the molecule contains one or more double bonds or triple bonds between the carbon atoms within the chain, or the homoserine lactone portion of the molecule contains a sulfur in the ring.
4 more elements
A pharmaceutical composition comprising at least one compound of the following formulae:
- wherein R1–R21 are selected from the group consisting of H, C1–C4 alkyl group, OH, NH2, SH or a halogen, wherein the halogen is selected from the group consisting of fluorine, chlorine, bromine, and iodine;
- R22 and R23 are selected from H, S, O, and N—Y,
- Y is selected from H, C1–C4 alkyl group, OH, NH2, SH or a halogen, wherein the halogen is selected from the group consisting of fluorine, chlorine, bromine, and iodine,
- R24–R28 is H or a halogen,
- X, X1 and X2 are selected from O, S, NH, H2, H plus OH or NH2, or any combination of H plus one halogen or two halogens when one or more R groups is substituted, and at least one of R1–R21 is halogen, or the alkylene chain of the molecule contains a sulfur in the chain;
- and
- wherein the alkylene chain of the molecule contains a nitrogen in the chain, or the alkylene chain of the molecule contains one or more double bonds or triple bonds between the carbon atoms within the chain, or the homoserine lactone portion of the molecule contains a sulfur in the ring.
- and a pharmaceutically acceptable carrier.
5 more elements
Dependencies are inferred from the claim text.