Activator for peroxisome proliferator-activated receptor
AssigneeNippon Chemiphar Co., Ltd.
InventorsShogo Sakuma, Tsuyoshi Endo, Takashi Kanda, Seiichiro Masui
Life of this patent
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Abstract
A phenylacetic acid derivative represented by the general formula (II) (wherein R11 and R12 each represents hydrogen, C1-8 alkyl, C1-8 alkoxy, C1-8 alkyl substituted by one to three halogen atoms, an optionally substituted phenyl, naphthyl, pyridyl, thienyl, or furyl group, etc.; X1 and Z1 each represents —C(═O)—, —C(═O)NH, —NHC(═O)—, —CH═CH—, a bond, etc.; and Y1 represents a C1-8 alkylene chain) or a salt of the derivative; and a PPARδ activator which contains the derivative or salt as the active ingredient
Claims4
A phenylacetic-acid derivative having the following formula (I) or a salt thereof:
- wherein
- each of R1 and R2 independently is a hydrogen atom, a halogen atom, nitro, an alkyl group having 1–8 carbon atoms, an alkoxy group having 1–8 carbon atoms, an alkyl group having 1–8 carbon atoms which has 1 to 3 halogen substituents, an alkoxy group having 1–8 carbon atoms which has 1 to 3 halogen substituents, an alkenyl group having 2–8 carbon atoms, an alkynyl group having 2–8 carbon atoms, a 3–7 membered cycloalkyl group, an alkyl group having 1–8 carbon atom which has a 3–7 membered cycloalkyl substituent, an aryl group having 6–10 carbon atoms which optionally has a substituent, an arylalkyl group which has a C6-10 aryl portion and C1-8 alkyl portion, a heterocyclic group which optionally has a substituent, or a heterocyclic-alkyl group having an alkyl group of 1–8 carbon atoms;
- A is an oxygen atom, a sulfur atom;
- each of X and Z independently is —C(═O)—, —C(═O)NH—, —C(═N—OR4)—, —CH(OR5)—, —NH (C═O)—, —NHSO2—, —SO2NH—, —CH═CH—, —C═C—, or a bond in which each of R4 and R5 is a hydrogen atom or an alkyl group having 1–8 carbon atoms;
- and
- Y is an alkylene chain having 1–8 carbon atoms.
A phenylacetic acid derivative having the following formula (II) or a salt thereof:
- wherein
- each of R11 and R12 independently is a hydrogen atom, a halogen atom, nitro, hydroxyl, amino, an alkyl group having 1–8 carbon atoms, an alkoxy group having 1–8 carbon atoms, an alkyl group having 1–8 carbon atoms which has 1 to 3 halogen substituents, an alkoxy group having 1–8 carbon atoms which has 1 to 3 halogen substituents, an alkenyl group having 2–8 carbon atoms, an alkynyl group having 2–8 carbon atoms, a 3–7 membered cycloalkyl group, an alkyl group having 1–8 carbon atoms which has a 3–7 membered cycloalkyl substituent, or a phenyl, naphthyl, benzyl, phenethyl, pyridyl, thienyl, furyl, quinolyl, or benzothienyl group which optionally has a substituent selected from the group consisting of a halogen atom, nitro, hydroxyl, amino, an alkyl group having 1–8 carbon atoms, an alkoxy group having 1–8 carbon atoms, an alkyl group having 1–8 carbon atoms which has 1 to 3 halogen substituents, an alkoxy group having 1–8 carbon atoms which has 1 to 3 halogen substituents, an alkenyl group having 2–8 carbon atoms, an alkynyl group having 2–8 carbon atoms, a 3–7 membered cycloalkyl group, an alkyl group having 1–8 carbon atoms which has a 3–7 membered cycloalkyl substituent, phenyl and pyridyl;
- each of X1—and Z1 independently is —C(═O)—, —C(═O)NH—, —C(═N—OR14)—, —CH(OR15)—, —NH(C═O)—, —NHSO2—, —SO2NH—, —CH═CH—, —C═C—, or a bond in which each of R14 and R15 is a hydrogen atom or an alkyl group having 1–8 carbon atoms;
- and
- Y1 is an alkylene chain having 1–8 carbon atoms.
Dependencies are inferred from the claim text.