Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activity and their use as cardiovascular preparations

A compound of the formula (I)

• in which
• R1 and R2 are attached to adjacent phenyl ring atoms and together with the two ring carbon atoms form a 5- or 6-membered saturated or partially unsaturated ring which may contain one or two oxygen atoms and which may be mono- or disubstituted, independently of one another, by (C1–C4)-alkyl which may be substituted by hydroxyl, (C1–C4)-alkoxy or phenyl;
• cyano;
• halogen;
• or oxo;
• R3 represents (C1–C8)-alkyl which may be substituted up to three times, independently of one another, by hydroxyl, (C1–C4)-alkoxy, (C3–C7)-cycloalkyl, (C2–C4)-alkenyl, (C2–C4)-alkynyl, halogen or (C6–C10)-aryloxy;
• (C6–C10)-aryl which may be substituted up to three times, independently of one another, by halogen, nitro, (C1–C4)-alkoxy, carboxyl, (C1–C4-alkoxycarbonyl or mono- or di-(C1–C4)-alkylamino;
• (C1–C8)-alkoxy which may be substituted by hydroxyl, (C1–C4)-alkoxy, (C3–C6)-cycloalkyl, (C2–C4)-alkenyl, (C6–C10)-aryl, 5- to 10-membered heteroaryl having up to three heteroatoms from the group consisting of N, O and/or S, (C6–C10)-aryloxy, halogen, cyano, (C1–C4)-alkoxycarbonyl, amino or mono- or di-(C1–C4)-alkylamino;
• hydrogen;
• hydroxyl;
• halogen;
• nitro;
• cyano;
• or —NH—C(O)—R5;
• in which
• R5 represents (C1–C8)-alkyl, which may be substituted by hydroxyl or (C1–C4)-alkoxy;
• or (C3–C7)-cycloalkyl or (C6–C10)-aryl, which may be substituted up to three times, independently of one another, by halogen, nitro, (C1–C4)-alkoxy, carboxyl, (C1–C4)-alkoxycarbonyl or mono- or di-(C1–C4)-alkylamino, and
• R4 represents (C2–C4)-alkenyl, (C3–C7)-cycloalkyl or (C1–C8)-alkyl, where alkyl may be substituted up to three times, independently of one another, by halogen, trifluoromethyl, trifluoromethylthio, (C3–C7)-cycloalkyl, hydroxyl, —CO—NH—R6, (C1–C4)-alkoxy, (C1–C4-alkoxycarbonyl, (C2–C4)-alkenyl, (C6–C10))-aryl or 5- to 10-membered heteroaryl having up to three heteroatoms and/or hetero chain members selected from the group consisting of N, NO(N oxide), O and S,
• where
• aryl and heteroaryl may be substituted up to three times, independently of one another, by halogen;
• trifluoromethyl;
• (C1–C4)-alkyl which may be substituted by carboxyl or (C1–C4)-alkoxycarbonyl;
• (C1–C4)-alkoxy;
• carboxyl;
• (C1–C4)-alkoxycarbonyl;
• amino;
• mono- or di-(C1–C4)-alkylamino;
• nitro;
• cyano;
• or hydroxyl;
• and
• R6 represents hydrogen;
• (C1–C8)-alkyl which may be substituted by hydroxyl or (C1–C4)-alkoxy;
• or (C3–C7)-cycloalkyl or (C6–C10)-aryl which may be substituted up to three times, independently of one another, by halogen, nitro, (C1–C4)-alkoxy, carboxyl, (C1–C4)-alkoxycarbonyl or mono- or di-(C1–C4)-alkylamino;
• or a salt, a hydrate, a hydrate of a salt or a solvate thereof.