Certain glycine derivatives as factor Xa inhibitors for use in the treatment of thrombotic disorders

A compound of formula (I)

• in which
• X1 represents CH;
• n is 1 or 2;
• each R represents hydrogen or methyl;
• R1 represents imidazol-1-yl or XaRa
• in which
• Xa represents O, S or NRb;
• Ra represents a hydrogen atom, a (1–4C)alkyl group, a phenyl group or a pyridyl group;
• Rb represents a hydrogen atom, a (1–4C)alkyl group or, together with Ra and the nitrogen atom to which they are attached represents a saturated 4 to 6-membered ring which may contain, as a ring member, one of O, S and NRc in which Rc represents hydrogen or (1–4C)alkyl;
• and
• R2 is selected from
• in which
• X2 represents a hydrogen atom, a halogen atom or an amino group;
• X3 represents a hydrogen atom, a methyl group, a fluorine atom, a chlorine atom or a bromine atom;
• X4 represents a hydrogen atom, a methyl group or a halogen atom;
• X5 represents a chlorine atom, a methoxy group or a methyl group;
• and
• X6 represents a hydrogen atom, a halogen atom or a methyl group;
• or a pharmaceutically acceptable salt thereof.