Method of treating disorder related to high cholesterol concentration
AssigneeArch Development Corporation
InventorsChing Song, Shutsung Liao
Life of this patent
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Abstract
A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.
Claims25
A method of treating atherosclerosis in a subject in need thereof, comprising administering to the subject a compound of formula (I):
- wherein
- R1, R2, R4, R5, R7, R11, R12R15, R16, and R20 are independently hydrogen, halo, alkyl, haloalkyl, hydroxy, amino, carboxyl, oxo, sulfonic acid, or alkyl that is optionally substituted at one or more positions with —NH—, —N(alkyl)-, —O—, —S—, —SO—, —SO2—, —O—SO2—, —SO2—O—, —SO3—O—, —CO—, —CO—O—, —O—CO—, —CO—NR′—, or —NR′—CO—;
- each of R3 and R6 is hydroxy;
- R8, R9, R10, R13, and R14 are independently hydrogen, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or amino;
- n is 0, 1, or 2;
- A is alkylene, alkenylene, or alkynylene;
- one of X, Y, and Z is OR′, and the other two are independently C1-8 haloalkyl;
- and
- R′ is hydrogen,
- or a salt, an ester, an amide, an enantiomer, an isomer, a tautomer, or a polymorph thereof.
A method for lowering blood serum cholesterol concentration in a subject in need thereof, comprising administering to the subject a compound of formula (I):
- wherein
- R1, R2, R4, R5, R7, R11, R12, R15, R16, and R20 are independently hydrogen, halo, alkyl, haloalkyl, hydroxy, amino, carboxyl, oxo, sulfonic acid, or alkyl that is optionally substituted at one or more positions with —NH—, —N(alkyl)-, —O—, —S—, —SO—, —SO2—, —O—SO2—, —SO2—O—, —SO3—O—, —CO—, —CO—O—, —O—CO—, —CO—NR′—, or —NR′—CO—;
- each of R3 and R6 is hydroxy;
- R8, R9, R10, R13, and R14 are independently hydrogen, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or amino;
- n is 0, 1, or 2;
- A is alkylene, alkenylene, or alkynylene;
- one of X, Y, and Z is OR′, and the other two are independently C1-8 haloalkyl;
- and
- R′ is hydrogen;
- or a salt, an ester, an amide, an enantiomer, an isomer, a tautomer, or a polymorph thereof.
Dependencies are inferred from the claim text.