Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling

A method of treating a cancer, in a subject in need thereof;

• wherein said cancer is hormone independent and wherein said cancer is susceptible to being treated by inhibition or arresting of cell cycling, by a cyclic compound or pharmaceutically active salt thereof, said method comprising inhibiting or arresting cell cycling by the cyclic compound or pharmaceutically active salt thereof by administering to said subject, the cyclic compound or a pharmaceutically active salt thereof in an amount sufficient to, inhibit or arrest cell cycling and thus treat the cancer susceptible to being treated, inhibition or arresting of cell cycling by the cyclic compound or pharmaceutically active salt thereof, wherein the cyclic compound comprises a polycyclic ring structure to which is attached a Group I and a Group II, independently of each other, wherein the polycyclic ring structure has the formula:
• wherein each ring A, B, C and D of ring system A B C D is optionally independently further substituted or unsubstituted, saturated or unsaturated;
• and
• wherein Group I is a hydrocarbyl or an oxyhydrocarbyl group;
• and
• wherein Group II is a group of the formula
• wherein each of R1 and R2 is independently selected from H or alkyl, cycloalkyl, alkenyl, or aryl, or together represent alkylene, which optionally contain one or more hereto atoms.