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US 7,078,390 B1Granted
Ribozymes to growth factor originating in human platelet
AssigneeGentier Biosystems Incorporation
InventorNoboru Fukuda
Life of this patent
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Abstract
A ribozyme comprising the following nucleotide sequence (SEQ ID NO:14) (I): 3′-GUGCCCCA GUACGGUG-5′ A C A UGA G AGU N3 N1 N2 wherein A, C, G and U represent a ribonucleotide whose base component is adenine, cytosine, guanine and uracil, respectively, N1 and N3 are at least one pair of nucleotides capable of forming a complementary base pair with each other, and N2 is at least three nucleotides capable of forming a loop.
Claims11
A ribozyme comprising the following nucleotide sequence (I′):
- 5′-GUGGCAUGCUGAUGANNNNNGAAACCCCGUG-3′ (I′) (SEQ ID NO:16) wherein A, C, G and U represent a ribonucleotide whose base component is adenine, cytosine, guanine and uracil, respectively, wherein the sequence of NNNNN contains at least two nucleotides capable of forming a complementary base pair with each other and three nucleotides capable of forming a loop.
Dependencies are inferred from the claim text.