Methods of inducing ovulation
AssigneeApplied Research Systems ARS Holding N.V.
InventorsStephen Palmer, Sean McKenna, Mark Tepper, Aliza Eshkol, Michael C. MacNamee
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Abstract
The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
Claims17
A method of combined treatment for stimulating follicular development and ovulation induction in a female host comprising:
- (a) administering an agent which increases follicle stimulating hormone concentrations in the host during the follicular phase of the host's ovulatory cycle;
- and
- (b) administering an inhibitor of a phosphodiesterase 4 isoform to the host prior to the luteal phase of the host's ovulatory cycle.
Dependencies are inferred from the claim text.