Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
AssigneeRaven biothechnologies, inc.
InventorsPenelope E Roberts, Jennie Powell Mather
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Abstract
The invention discloses a substantially pure population of human pancreatic progenitor cells and methods of isolating and culturing the pancreatic progenitor cells. By carefully manipulating the microenvironment of the pancreatic progenitor cells, multiple passages are attainable wherein the pancreatic progenitor cells do not senesce and furthermore, are capable of becoming functional exocrine or endocrine cells. In addition, several methods of use of human pancreatic progenitor cells are disclosed herein.
Claims18
A method of providing cell therapy to a human recipient lacking or having functionally defective pancreatic epithelial cells, comprising administering to the human recipient an isolated, substantially pure population of human pancreatic progenitor cells that are capable of differentiating into acinar, ductal, and islet cells, wherein said administration is made to the pancreas of the human recipient.
A method of providing cell therapy to a human recipient lacking or having functionally defective pancreatic epithelial cells, comprising administering to the human recipient an isolated, substantially pure population of human pancreatic progenitor cells that are capable of differentiating into acinar, ductal and islet cells, wherein said administration is made to the kidney capsule of the human recipient.
Dependencies are inferred from the claim text.