Antibiotics AA-896
AssigneeWyeth Holdings Corporation
InventorsGuy Thomas Carter, Jason Arnold Lotvin, Leonard Alexander McDonald
Life of this patent
Estimating the term…
Abstract
This invention relates to new antibiotics designated AA-896-A1, AA-896-A2, AA-896-A3, AA-896-A4, AA-896-A5, AA-896-A6, AA-896-Bl, AA-896-B2, AA-896-B3, AA-896-B4, AA-896-B5, AA-896-B6, AA-896-B7, AA-896-C1, AA-896-C2, AA-896-C3, AA-896-C4, AA-896-C5, AA-896-D1, AA-896-D2, AA-896-D3 and AA-896-D4 derived from the microorganism Streptomyces spp. LL-AA896 which are useful an anti-bacterial agents.
Claims21
A process for producing a antibiotic AA-896 compound of the formula
- wherein:
- or pharmaceutically acceptable salts thereof
- said process comprising:
- cultivating a producing strain of Streptomyces spp. selected from the group LL4774, LL4794, LL4802, LL4808 and LL4892 or an antibiotic AA-896 producing mutant thereof, under aerobic conditions, in a suitable culture medium until a recoverable amount of said antibiotic AA-896 compound is formed in said medium and recovering said antibiotic AA-896 compound therefrom.
A process for producing a antibiotic AA-896 compound of the formula
- wherein:
- or pharmaceutically acceptable salts thereof
- said process comprising:
- cultivating a producing strain of Streptomyces spp. selected from the group LL4774, LL4794, LL4802, LL4808, LL4879 and LL4892 or an antibiotic AA-896 producing mutant thereof, under aerobic conditions, in a suitable culture medium until a recoverable amount of said antibiotic AA-896 compound is formed in said medium and recovering said antibiotic AA-896 compound therefrom.
A process for producing a antibiotic AA-896 compound of the formula
- wherein:
- or pharmaceutically acceptable salts thereof
- said process comprising:
- cultivating a producing strain of Streptomyces spp. selected from the group LL4774, LL4794, LL4802, LL4808, LL4879, LL4889 and LL4892 or an antibiotic AA-896 producing mutant thereof under aerobic conditions, in a suitable culture medium until a recoverable amount of said antibiotic AA-896 compound is formed in said medium and recovering said antibiotic AA-896 compound therefrom.
A process for producing a antibiotic AA-896 compound of the formula
- or pharmaceutically acceptable salts thereof
- said process comprising:
- cultivating a producing strain of Streptomyces spp. selected from the group LL4774, LL4794, LL4802, LL4808, LL4879 and LL4892 or an antibiotic AA-896 producing mutant thereof, under aerobic conditions, in a suitable culture medium until a recoverable amount of said antibiotic AA-896 compound is formed in said medium and recovering said antibiotic AA-896 compound therefrom.
A process for producing a antibiotic AA-896 compound of the formula
- or pharmaceutically acceptable salts thereof
- said process comprising:
- cultivating a producing strain of Streptomyces spp. selected from the group LL4774, LL4794, LL4802, LL4808, LL4879, LL4889 and LL4892 or an antibiotic AA-896 producing mutant thereof, under aerobic conditions, in a suitable culture medium until a recoverable amount of said antibiotic AA-896 compound is formed in said medium and recovering said antibiotic AA-896 compound therefrom.
An isolated microorganism Streptomyces spp. LL-AA896, strain LL4774 or an AA-896 antibiotic producing mutant thereof.
A process for producing a antibiotic AA-896 compound of the formula
- or pharmaceutically acceptable salts thereof
- wherein:
- said process comprising:
- cultivating a producing strain of Streptomyces spp. selected from the group LL4774, LL4794, LL4802, LL4808, LL479 and LL482 or an antibiotic AA-896 producing mutant thereof under aerobic conditions, in a suitable culture medium until a recoverable amount of said antibiotic AA-896 compound is formed in said medium and recovering said antibiotic AA-896 compound therefrom.
A process for producing a antibiotic AA-896 compound of the formula
- wherein:
- R1 is H or
- R2 is H, OH or OCH3;
- R3 is H or CH3;
- R4is represented by the formula
- n is an integer from 4 to 12;
- R5 is straight and branched alkyl of 1 to 4 carbon atoms, carbamimidoylamino or carbamimidoylhydroxyamino;
- or a pharmaceutically acceptable salt thereof
- said process comprising:
- cultivating a producing strain of Streptomyces spp. selected from the group LL4774, LL4794, LL4802, LL4808, LL479, LL469 and LL482 or an antibiotic AA-896 producing mutant thereof, under aerobic conditions, in a suitable culture medium until a recoverable amount of said antibiotic AA-896 compound is formed in said medium and recovering said antibiotic AA-896 compound therefrom.
Dependencies are inferred from the claim text.