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US 7,078,028 B2Granted
Anti-neoplastic viral agents
AssigneeBTG International Limited
InventorsRichard Iggo, Michele Alberto Brunori
Life of this patent
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AssigneeBTG International Limited
InventorsRichard Iggo, Michele Alberto Brunori
Estimating the term…
A viral DNA construct, and virus encoded thereby, is provided having one or more tumour specific transcription factor binding sites in place of one or more wild type transcription factor binding sites operatively positioned in the promoter region which controls expression of early genes responsible for viral nucleic acid replication. Preferred constructs place the tumour specific transcription factor binding sites in operative relation to DNA polymerase, DNA terminal protein and/or DNA binding protein. Compositions and constructs contained therein are provided, particularly for use in therapy. Methods of treating patients for neoplasms are also provided.
A viral DNA construct encoding for an adenovirus capable of replication in a human or animal tumor cell and causing death of such tumor cells, wherein the adenovirus comprises one or more Tcf-4 sites of multiple consensus sequence of 2 to 6 repeats of (A/T)(A/T)CAA(A/T)GG operatively positioned to promote expression of each of the viral polymerase, DNA terminal protein and DNA binding protein open reading frames, and wherein at least one E2 early promoter transcription factor binding site, not overlapped by coding sequence, is replaced by said Tcf-4 site(s) such as to reduce expression of said open reading frames of said construct as compared to wild type virus in normal human or animal cells.
Dependencies are inferred from the claim text.