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US 7,071,464 B2Granted
Mass spectroscopy system
AssigneeDana-Farber Cancer Institute, Inc.
InventorBruce Reinhold
Life of this patent
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Abstract
The invention features a method including: i) confining ions to stable trajectories within an ion trap; ii) exciting a subset of the ions along at least one transverse coordinate; iii) rotating the transverse excitation into an excitation along an axial coordinate; and iv) transferring at least some of the axially excited ions from the ion trap along the axial coordinate. For example, the ions may be transferred to an ion detector or to a subsequent ion trap.
Claims87
A method comprising:
- confining ions to stable trajectories within an ion trap;
- exciting a subset of the ions along at least one transverse coordinate;
- rotating the transverse excitation into an excitation along an axial coordinate;
- and
- transferring at least some of the axially excited ions from the ion trap along the axial coordinate.
2 more elements
An apparatus comprising:
- a housing comprising a chamber for receiving ions and multiple electrodes surrounding the chamber, wherein the multiple electrodes define transverse and axial coordinates for ion motion within the chamber;
- a set of power supplies coupled to the multiple electrodes;
- and
- an electronic controller coupled to the set of power supplies, wherein during operation the electronic controller causes the set of power supplies to generate a series of electric fields in the chamber that:
- i) confines ions to stable trajectories within the chamber;
- ii) excites a subset of the ions along at least one of the transverse coordinates;
- iii) rotates the transverse excitation into an excitation along the axial coordinate;
- and iv) transfers at least some of the axially excited ions from the ion trap along the axial coordinate.
5 more elements
An apparatus comprising:
- a housing comprising a chamber for receiving ions and multiple electrodes surrounding the chamber, wherein the multiple electrodes define transverse and axial coordinates for ion motion within the chamber;
- a set of power supplies coupled to the multiple electrodes;
- and
- a electronic controller coupled to the set of power supplies, wherein during operation the electronic controller is configured to cause the set of power supplies to generate a time-dependent electric field along at least one of the transverse coordinates, and further configured to cause the set of power supplies to generate a time-dependent electric field that couples the axial coordinate to the transverse coordinate.
1 more element
A method comprising:
- generating an axially extended RF trapping field to transversely confine ions;
- providing a spatially localized modification in the extended RF trapping field, wherein the modification imparts an axial force on incident ions that varies with a mass-to-charge ratio of each incident ion;
- and
- directing ions from a first trapping region to the spatially localized modification to allow some of the ions from the first trapping region to penetrate though the spatially localized modification and not others.
1 more element
An apparatus comprising:
- electrodes configured to produce an axially extended RF trapping field that transversely confines ions, wherein the electrodes are modified to produce a spatially localized region in the axially extended RF trapping field that imparts an axial force on incident ions that varies with a mass-to-charge ratio of each incident ion;
- a set of power supplies including at least direct current (DC) and RF power supplies coupled to the electrodes;
- and
- an electronic controller coupled to the set of power supplies, wherein during operation the electronic controller causes the set of power supplies to:
- i) generate the axially extended RF trapping field and the spatially localized region in the axially extended RF trapping field;
- and ii) direct ions from a first trapping region to the spatially localized region to allow some of the ions from the first trapping region to penetrate though the spatially localized region and not others.
3 more elements
A method comprising:
- generating an axially extended RF trapping field to transversely confine ions;
- providing a spatially localized modification in the extended RF trapping field, wherein the modification imparts an axial force on incident ions that varies with a transverse displacement of each incident ion;
- increasing a transverse oscillation amplitude of a subset of the ions from a first ion trapping region, wherein the subset of ions comprises ions having a selected mass-to-charge ratio;
- and
- directing the ions toward the spatially localized modification to cause some of the ions to penetrate through it and not others.
2 more elements
An apparatus comprising:
- electrodes configured to produce an axially extended RF trapping field that transversely confines ions, wherein the electrodes are modified to produce a spatially localized region in the axially extended RF trapping field that imparts an axial force on incident ions that varies with a transverse displacement of each incident ion;
- a set of power supplies including at least direct current (DC) and RF power supplies coupled to the electrodes;
- and
- an electronic controller coupled to the set of power supplies, wherein during operation the electronic controller causes the set of power supplies to:
- i) generate the axially extended RF trapping field and the spatially localized region in the axially extended RF trapping field;
- ii) increase a transverse oscillation amplitude of a subset of the ions from a first ion trapping region, wherein the subset of ions comprises ions having a selected mass-to-charge ratio;
- and iii) direct the ions toward the spatially localized modification to cause some of the ions to penetrate through it and not others.
4 more elements
An apparatus comprising:
- electrodes configured to produce an axially extended RF trapping field that transversely confines ions, wherein the electrodes are modified to produce a spatially localized region within the axially extended RF trapping field that imparts an axial force on incident ions, wherein the axial force varies with a mass-to-charge ratio of each incident ion;
- and
- a set of power supplies including at least direct current (DC) and RF power supplies coupled to the electrodes.
Dependencies are inferred from the claim text.