Stabilized activated derivatives of carbamic acid, their process of preparation and their use for the preparation of ureas

A compound having the formula (I bis)

• wherein
• “n” is 1 or 2,
• “i” is a whole number varying from 2 to n+1,
• GP is selected from the group consisting of:
• an oxycarbonyl group ROCO, R representing an alkyl group of 1 to 20 carbon atoms, unsubstituted or substituted with an aryl group whose cyclic structure contains 5 to 20 carbon atoms, said alkyl group being saturated or not,
• an acyl group RCO, R being chosen from:
• an alkyl group of 1 to 20 carbon atoms or an aryl group whose cyclic structure contains 5 to 20 carbon atoms, said alkyl group being possibly substituted with an aryl group whose cyclic structure contains 5 to 20 carbon atoms, said alkyl group being saturated or not,
• GP along with R1 and the N then are bonded to form a phthalimido group of formula:
• a biotinyle group having the following formula
• groups R1 and Ri can each represent independently from each other:
• a hydrogen, a halogen, the protected or unprotected side chain of an amino acid selected from natural and synthetic amino acids, a (C1–C20) alkyl group, unsubstituted or substituted, an aryl group whose cyclic structure contains 5 to 20 carbon atoms, a group ORa, —NH2, —OH, —COORa, —CONHRa, —CONH2, —CH2COORa, —CH2CONHRa, —CH2CONH2,
• Ra representing an alkyl group, saturated or not, having 1 to 20 carbon atoms, an aralkyl group having 1 to 20 carbon atoms, or an aryl group whose cyclic structure contains 5 to 20 carbon atoms,
• R1 and Ri groups can also form a cycle with N, said cycle being selected from the group consisting of
• X group represents a group having one of the following formula:
• wherein said compound is not one of the following compounds selected from the group consisting of:
• n=2, GP=Boc, R1=isobutyl, R2=R3=H, X=4-nitrophenol;
• n=2, GP=Boc, R1=benzyl, R2=R3=H, X=4-nitrophenol;
• n=2, GP=Boc, R1=CH2-p-C6H4Ot-Bu, R2=R3=H, X=4-nitrophenol;
• n=2, GP=Boc, R1=H, R2=R3=H, X=4-nitrophenol.