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US 7,029,674 B2Granted
Methods for downmodulating immune cells using an antibody to PD-1
AssigneeWyeth
InventorsBeatriz M. Carreno, John Leonard
Life of this patent
Estimating the term…
Abstract
Disclosed are methods for downmodulating an immune response comprising contacting an immune cell with an agent that modulates the interaction between PD-1 and a PD-1 ligand (e.g., soluble forms of PD-1 or PD-1 ligand or antibodies to PD-1) to thereby modulate the immune response.
Claims7
A method for downmodulating activation of an immune cell, comprising contacting an immune cell, at the time of contact with antigen, with an agent that inhibits signaling via PD-1 to thereby downmodulate activation of an immune cell, wherein the agent is a monovalent antibody that binds to PD-1.
Dependencies are inferred from the claim text.