Method for virus propagation
AssigneeBavarian Nordic A/S
InventorsPaul Howley, Karl Heller, Ingmar Räthe
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Abstract
The present invention relates to a process for producing poxvirus, in particular Chordopoxvirus, wherein the poxvirus is cultivated at a temperature below 37° C. The process leads to increased virus propagation at the decreased temperature.
Claims28
A process of amplifying a Chordopoxvirus characterized in that the virus is propagated in culture media at a cultivation temperature below 37° C., wherein the chordopoxvirus is selected from Avipoxvirus and modified vaccinia virus Ankara (MVA).
Process of amplifying a Chordopoxvirus characterized in that the virus is propagated in chicken embryo fibroblasts at a cultivation temperature of 26° C. to 32° C.
Dependencies are inferred from the claim text.