Pharmaceutical and cosmetic carrier or composition for topical application
AssigneeFoamix Ltd.
InventorsMeir Eini, Dov Tamarkin
Life of this patent
Estimating the term…
Abstract
A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1-25 percent of a solidifying agent and 75-99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.
Claims42
A pharmaceutical or cosmetic carrier, consisting essentially of:
- less than or equal to about 10 percent by weight of a solidifying agent, said solidifying agent consisting essentially of a long chain fatty alcohol having at least 15 carbon atoms in its carbon backbone and a fatty acid having at least 18 carbon atoms in its carbon backbone;
- and
- 75-99 percent by weight of a hydrophobic solvent, wherein the carrier is semi-solid at rest and liquefies upon its application of shear forces thereto.
A method of preparing a pharmaceutical or cosmetic carrier, the method comprising the steps of:
- (a) mixing a hydrophobic solvent and a solidifying agent at a temperature above a melting temperature of the solidifying agent so as to obtain a mixture containing 75-99 percent by weight of the hydrophobic solvent and less than or equal to about 10 percent by weight of a solidifying agent, said solidifying agent consisting essentially of a long chain fatty alcohol having at least 15 carbon atoms in its carbon backbone and a fatty acid having at least 18 carbon atoms in its carbon backbone;
- and
- (b) cooling the mixture.
A pharmaceutical or cosmetic composition consisting essentially of:
- (a) a pharmaceutical or cosmetic carrier containing less than or equal to about 10 percent by weight of a solidifying agent, said solidifying agent consisting essentially of a long chain fatty alcohol having at least 15 carbon atoms in its carbon backbone and a fatty acid having at least 18 carbon atoms in its carbon backbone, and 75-99 percent by weight of a hydrophobic solvent;
- and
- (b) a therapeutically or cosmetically effective amount of a biologically active substance.
A method of preparing a pharmaceutical or cosmetic composition, the method comprising the steps of
- (a) mixing a hydrophobic solvent and a solidifying agent at a temperature above a melting temperature of the solidifying agent so as to obtain a pharmaceutical or cosmetic mixture containing 75-99 percent by weight of the hydrophobic solvent and less than or equal to about 10 percent by weight of the solidifying agent, said solidifying agent consisting essentially of a long chain fatty alcohol having at least 15 carbon atoms in its carbon backbone and a fatty acid having at least 18 carbon atoms in its carbon backbone;
- and
- (b) further mixing into said carrier mixture a therapeutically or cosmetically effective amount of a biologically active substance.
Dependencies are inferred from the claim text.